Sunday, 15 May 2011


Metformin Hydrochloride (Metaformin HCL)

Metformin Hydrochloride is an oral antihyperglycemic drug belonging to biguanide class. Metformin aids in the management of type 2 diabetes. Metformin HCL (N,N -dimethylimidodicarbonimidic diamide monohydrochloride) is not chemically or pharmacologically related to sulfonylureas, thiazolidinediones, or (alpha)-glucosidase inhibitors. It is a white to off-white crystalline compound.

Metformin Hydrochloride is an antihyperglycemic agent that improves glucose tolerance in patients, lowering both basal and postprandial plasma glucose.

The absolute bioavailability of a 500mg Metformin HCl tablet under fasting conditions is approximately 50-60%.

Food decreases the entent of and marginally delays the absorption of metformin.

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